2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Emibetuzumab

Emibetuzumab  (Synonyms: 依玛妥珠单抗; LY2875358)

目录号: HY-P99192 纯度: 95.00%
COA

摩尔计算器

Emibetuzumab (LY2875358) 是一种人源化二价 MET 抗体 (IgG4 型)。Emibetuzumab 具有较高的中和与内化活性，能有效抑制 HGF 依赖性和非依赖性 MET 通路的激活和肿瘤生长。Emibetuzumab 可用于癌症的研究。

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CAS No. : 1365287-97-3

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规格 价格 是否有货 数量
1 mg ￥1800
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5 mg ￥5400
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10 mg ￥8600
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Emibetuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

MET[1].
体外研究
(In Vitro)

Emibetuzumab (LY2875358) (100 nmol/L; 6 days) inhibits HGF-stimulated proliferation of H596[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Emibetuzumab 相关抗体:

Cell Proliferation Assay[1]

Cell Line: H596 cells (HGF-stimulated)
Concentration: 100 nmol/L
Incubation Time: 6 days
Result: Suppressed cell proliferation.
体内研究
(In Vivo)

Emibetuzumab (LY2875358) (10 mg/kg; i.v.; once a week for 5 weeks) inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice[1].
Emibetuzumab (10 or 20 mg/kg; i.v.; single) downregulates levels of MET and pMET in the tumors of mice[1].
Emibetuzumab (10 mg/kg; i.v.; once a week for 3, 5 or 6 weeks) exhibits antitumor effects on MET-amplified xenograft mouse tumor models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (U87MG tumor xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 5 weeks.
Result: Demonstrated a significant inhibition of tumor growth.
Animal Model: Athymic nude mice (MKN45 xenograft tumor model)[1].
Dosage: 10 or 20 mg/kg
Administration: Intravenous injection, single.
Result: Reduced MET and pMET in the tumors by approximately 50% at both the 10 and 20 mg/kg doses by 72 hours post dose, and the reductions persisted to 14 days.
Animal Model: Athymic nude mice (MET-amplified xenograft mouse tumor models)[1].
Dosage: 10 mg/kg
Administration: Intravenous injection, once a week for 3, 5 or 6 weeks.
Result: Resulted in a marked reduction in tumor growth in the MKN45/SNU-5/EBC-1 gastric xenograft tumors.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依玛妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料

纯度: 95.00%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Emibetuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emibetuzumab1365287-97-3LY2875358依玛妥珠单抗LY 2875358LY-2875358c-Met/HGFRcancerH596tumorMKN45SNU-5EBC-1Inhibitorinhibitorinhibit

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